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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1998 2
1999 3
2000 1
2001 5
2002 3
2003 7
2004 3
2005 5
2006 4
2007 10
2008 8
2009 11
2010 11
2011 8
2012 16
2013 15
2014 14
2015 9
2016 25
2017 15
2018 16
2019 14
2020 21
2021 16
2022 12
2023 9
2024 3

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233 results

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Page 1
Colorectal cancer organoid models uncover oxaliplatin-resistant mechanisms at single cell resolution.
Chen G, Gong T, Wang Z, Wang Z, Lin X, Chen S, Sun C, Zhao W, Kong Y, Ai H, Yang H, Liu Y, Wu F, Kang J, Zhao S, Xiao X, Sun J, He A, Li Z. Chen G, et al. Cell Oncol (Dordr). 2022 Dec;45(6):1155-1167. doi: 10.1007/s13402-022-00705-5. Epub 2022 Sep 22. Cell Oncol (Dordr). 2022. PMID: 36136268
The data also revealed several putative drug resistant-driven genes (STMN1, VEGFA and NDRG1) and transcription factors (E2F1, BRCA1, MYBL2, CDX2 and CDX1). CONCLUSION: We generated an oxaliplatin-resistant CRC organoid model that was employed to provide potential therapeut …
The data also revealed several putative drug resistant-driven genes (STMN1, VEGFA and NDRG1) and transcription factors (E2F1, BRCA1, MYBL2, …
Pulmonary enteric adenocarcinoma: an overview.
Palmirotta R, Lovero D, D'Oronzo S, Todisco A, Internò V, Mele F, Stucci LS, Silvestris F. Palmirotta R, et al. Expert Rev Mol Med. 2020 Apr 28;22:e1. doi: 10.1017/erm.2020.2. Expert Rev Mol Med. 2020. PMID: 32340641 Review.
PAED exhibits an 'entero-like' pathological morphology in more than half cases, expressing at least one of the typical immunohistochemical markers of enteric differentiation, namely CDX2, CK20 or MUC2. For this reason, this malignancy appears often indistinguishable from a …
PAED exhibits an 'entero-like' pathological morphology in more than half cases, expressing at least one of the typical immunohistochemical m …
JARID1B promotes colorectal cancer proliferation and Wnt/beta-catenin signaling via decreasing CDX2 level.
Huang D, Xiao F, Hao H, Hua F, Luo Z, Huang Z, Li Q, Chen S, Cheng X, Zhang X, Fang W, Hu X, Liu F. Huang D, et al. Cell Commun Signal. 2020 Oct 27;18(1):169. doi: 10.1186/s12964-020-00660-4. Cell Commun Signal. 2020. PMID: 33109187 Free PMC article.
In addition, we found that JARID1B promoted CRC cells proliferation by Wnt/beta-catenin signaling pathway. Further studies demonstrated CDX2 as a downstream target of JARID1B, and our data demonstrated that CDX2 is crucial for JARID1B -mediated Wnt/beta-catenin sign …
In addition, we found that JARID1B promoted CRC cells proliferation by Wnt/beta-catenin signaling pathway. Further studies demonstrated C …
Impact of homeobox genes in gastrointestinal cancer.
Joo MK, Park JJ, Chun HJ. Joo MK, et al. World J Gastroenterol. 2016 Oct 7;22(37):8247-8256. doi: 10.3748/wjg.v22.i37.8247. World J Gastroenterol. 2016. PMID: 27729732 Free PMC article. Review.
In gastrointestinal (GI) cancers, most studies have focused on the function of non-HOX genes including caudal-related homeobox transcription factor 1 (CDX1) and CDX2. CDX2 is a crucial factor in the development of pre-cancerous lesions such as Barrett's esophagus or …
In gastrointestinal (GI) cancers, most studies have focused on the function of non-HOX genes including caudal-related homeobox transcription …
Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer.
Bruun J, Sveen A, Barros R, Eide PW, Eilertsen I, Kolberg M, Pellinen T, David L, Svindland A, Kallioniemi O, Guren MG, Nesbakken A, Almeida R, Lothe RA. Bruun J, et al. Mol Oncol. 2018 Sep;12(9):1639-1655. doi: 10.1002/1878-0261.12347. Epub 2018 Aug 15. Mol Oncol. 2018. PMID: 29900672 Free PMC article.
For individual stages, CDX2 was prognostic only in stage IV, independent of chemotherapy. ...The CDX2-negative cell lines were significantly more sensitive to chemotherapeutics than CDX2-positive cells, and the multidrug resistance genes MDR1 and CFTR were si …
For individual stages, CDX2 was prognostic only in stage IV, independent of chemotherapy. ...The CDX2-negative cell lines were …
Cdx2 Animal Models Reveal Developmental Origins of Cancers.
Chawengsaksophak K. Chawengsaksophak K. Genes (Basel). 2019 Nov 14;10(11):928. doi: 10.3390/genes10110928. Genes (Basel). 2019. PMID: 31739541 Free PMC article. Review.
The Cdx2 homeobox gene is important in assigning positional identity during the finely orchestrated process of embryogenesis. ...This review will address how animal models have refined our understanding of the role of Cdx2 in these common human cancers....
The Cdx2 homeobox gene is important in assigning positional identity during the finely orchestrated process of embryogenesis. ...This …
Data Sharing.
Longo DL, Drazen JM. Longo DL, et al. N Engl J Med. 2016 Jan 21;374(3):276-7. doi: 10.1056/NEJMe1516564. N Engl J Med. 2016. PMID: 26789876 Free article.
CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway.
Graule J, Uth K, Fischer E, Centeno I, Galván JA, Eichmann M, Rau TT, Langer R, Dawson H, Nitsche U, Traeger P, Berger MD, Schnüriger B, Hädrich M, Studer P, Inderbitzin D, Lugli A, Tschan MP, Zlobec I. Graule J, et al. Clin Epigenetics. 2018 Sep 26;10(1):120. doi: 10.1186/s13148-018-0548-2. Clin Epigenetics. 2018. PMID: 30257705 Free PMC article.
Here, we aim to validate the clinical impact of CDX2 and investigate the role of promoter methylation and histone deacetylation in CDX2 repression and restoration. ...Lastly, decitabine co-treatment was more effective than LMK-235 alone at restoring CDX2. CON …
Here, we aim to validate the clinical impact of CDX2 and investigate the role of promoter methylation and histone deacetylation in …
CDX2 Protein Expression in Colorectal Cancer and ItsCorrelation with Clinical and Pathological Characteristics, Prognosis, and Survival Rate of Patients.
Asgari-Karchekani S, Karimian M, Mazoochi T, Taheri MA, Khamehchian T. Asgari-Karchekani S, et al. J Gastrointest Cancer. 2020 Sep;51(3):844-849. doi: 10.1007/s12029-019-00314-w. J Gastrointest Cancer. 2020. PMID: 31630373
Also, the CDX2 expression was significantly higher in adenocarcinoma than in mucinous. In addition, a significant correlation was found between downregulated CDX2 and lymph node involvement. In tumor grading, there was a significant correlation between CDX2 d …
Also, the CDX2 expression was significantly higher in adenocarcinoma than in mucinous. In addition, a significant correlation was fou …
Colorectal Adenocarcinomas Harboring ALK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 12 Cases and Review of the Literature.
Lasota J, Chłopek M, Wasąg B, Kowalik A, Christiansen J, Lamoureux J, Kuźniacka A, Felisiak-Gołąbek A, Liu Y, Reyes TAR, Saha R, Agaimy A, Behenska K, Biernat W, Cattaneo L, Centonze G, Daum O, Daumova M, Domagała P, Dziuba I, Geppert CE, Góźdź S, Nasierowska-Guttmejer A, Hałoń A, Hartmann A, Inaguma S, Iżycka-Świeszewska E, Kaczorowski M, Kołos M, Kopczyński J, Michal M, Milione M, Okoń K, Pęksa R, Pyzlak M, Ryś J, Waloszczyk P, Wejman J, Miettinen M. Lasota J, et al. Am J Surg Pathol. 2020 Sep;44(9):1224-1234. doi: 10.1097/PAS.0000000000001512. Am J Surg Pathol. 2020. PMID: 32804454 Free PMC article. Review.
In 4 carcinomas, tumor cells showed strong, focal (n=3), or diffuse programmed death-ligand 1 immunoreactivity. CDX2 expression and loss of CK20 and MUC2 expression were frequent. ...
In 4 carcinomas, tumor cells showed strong, focal (n=3), or diffuse programmed death-ligand 1 immunoreactivity. CDX2 expression and l …
233 results